Project title: Studying biological effects of alpha particles in vivo using zebrafish embryos

In recent years, the zebrafish, Danio rerio, a small vertebrate from Southeast Asia, has become a preferred model for studying human disease, including carcinogenesis. The most important advantage is that the human and zebrafish genomes share considerable homology, including conservation of most DNA repair-related genes. Rapid embryonic development is another advantage so the effects can be assessed within 24 hours post fertilization (hpf). The currently studied biological effects of alpha particles in vivo include (1) the hormetic effect, (2) the bystander effect, (3) the adaptive response, and (4) the rescue effect.

References:

Choi, V.W.Y., Konishi, T., Oikawa, M., Iso, H., Cheng, S.H., Yu, K.N., 2010. Adaptive response in zebrafish embryos induced using microbeam protons as priming dose and x-ray photons as challenging dose. Journal of Radiation Research 51, 657664.

Choi, V.W.Y., Yum, E.H.W., Konishi, T., Oikawa, M., Cheng, S.H., Yu, K.N., 2012. Triphasic low-dose response in zebrafish embryos irradiated by microbeam protons. Journal of Radiation Research 53, 475-481.

Supervisor: Prof Peter K N Yu (peter.yu@cityu.edu.hk)

Suitable for: M.Phil. or Ph.D.

Prerequisites:
A good degree in radiation biophysics or biology