Optical Biosensor Lab-on-a-Chips


Fluorescence, luminescence, and surface plasmon resonance are amongst the most sensitive and selective methods used in biological investigations, such as genetic and pathogenic analysis. However, instrumentation currently performing these techniques involves a large amount of conventional discrete optical components such as lenses, rendering the instrument complex, bulky, and expensive.


The goal of this project is to design, fabricate, and characterize miniaturized optical biosensors to meet the sensitivity, selectivity, portability, and cost requirements of current and emerging biosensing applications. We will take on a lenseless approach, where the samples are placed in close proximity to or in direct contact with the sensor. This technique is known as contact sensing. Solution-phase samples will be transported to the detectors by microfluidics, structures such as micro-channels and mixers that control and manipulate the flow of small volumes of fluids. 


The elimination of focusing optics enables miniaturized, sensitive, and low-cost optical biosensors, making possible their wide-spread use out of the laboratory.


Areas of study: optical sensor design, lab-on-a-chip design, contact sensing

Supervisor: Dr. Derek HO (derekho@cityu.edu.hk; www.atomstosystems.com)

Suitable for: M.Phil./Ph.D.