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Characterization of biological systems

BIological systems consist of a wide range of atoms and molecules assembled into complicated micro and macro structures. The elements, molecules, and structures vary between different parts of the body and between different species. Biological systems can also change considerably with disease or external treatments, such as medication. We apply a range of imaging and spectroscopy techniques to characterize a wide variety of biological systems. We are also developing novel methodologies to advance the characterization of biological systems.

 

 

fMRI image

Small animal functional magnetic resonance imaging

Functional magnetic resonance imaging (fMRI) is arguably the leading neuroimaging technique. fMRI permits noninvasive and in vivo neuroimaging with millimeter spatial resolution and whole brain field of view. To date, fMRI has primarily been applied in humans with considerable success. Animal models such as the rat have also made important contributions to neuroscience. Performing fMRI in animals provides an important link between human and animal neuroscience research. We have applied and developed fMRI technologies to study auditory and visual processing in the rat. This has enabled mapping of velocity encoding in the superior colliculus and tonotopic organization in the inferior colliculus. The newly developed swept source fMRI technology enables mapping tonotopic organization with superior frequency resolution and reduced image distortion compared to conventional fMRI approaches.

 

Funding

- City University of Hong Kong

- Hong Kong General Research Fund

- Hong Kong Health and Medical Research Fund